Cannabinoid Receptor 1
A cannabinoid receptor antagonist, also known simply as a cannabinoid antagonist or as an anticannabinoid, is a type of cannabinoidergic drug that binds to cannabinoid receptors (CBR) and prevents their activation by endocannabinoids. They include antagonists, inverse agonists, and antibodies of CBRs. The discovery of the endocannabinoid system led to the development of CB1 receptor antagonists.
Cannabinoid Receptor 2
Cannabinoid receptors are of a class of cell membrane receptors under the G protein-coupled receptor superfamily. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, produced by the mammillary body; plant cannabinoids (such as Cannabidiol, produced by the cannabis plant); and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and plant cannabinoids are lipophilic, such as fat soluble compounds.
Limonene is a monocyclic monoterpenoid and one of two major compounds formed from pinene. As the name suggests, varieties high in limonene have strong citrusy smells like oranges, lemons and limes. Strains high in limonene promote a general uplift in mood and attitude. This citrusy terpene is the major constituent in citrus fruit rinds, rosemary, juniper and peppermint, as well as in several pine needle oils.
Limonene is highly absorbed by inhalation and quickly appears in the bloodstream. It assists in the absorption of other terpenes through the skin and other body tissue. It is well documented that limonene suppresses the growth of many species of fungi and bacteria, making it an ideal antifungal agent for ailments such as toenail fungus. Limonene may be beneficial in protecting against various cancers, and orally administered limonene is currently undergoing clinical trials in the treatment of breast cancer. Limonene has been found to even help promote weight-loss.
Plants use limonene as a natural insecticide to ward off predators. Limonene was primarily used in food and perfumes until a couple of decades ago, when it became better known as the main active ingredient in citrus cleaner. It has very low toxicity and adverse effects are rarely associated with it.
What is Limonene and Its Effects or Benefits?
If you have ever tried a particular type of medical cannabis like Tangie or Super Lemon Haze, you might have noticed the distinct and refreshing smell of lemons. That comes from a chemical that occurs naturally in the cannabis flower. That chemical is called a terpene.
What is limonene in terms of a medicine? It does get include in household products and cosmetics. But, when it comes in the form of medicinal marijuana, it can have several benefits. The most notable is that of aiding in digestion. It is being used alone as a medicine to help certain people cure themselves of digestive or gastric reflux problems.
Some of the more noticeable benefits include its ability to heal heartburn, elevate mood and relieve stress. It also has antifungal and antibacterial properties. This is just another reason it is often included in cosmetics and household products.
For anyone interested in using medical marijuana for the above issues, it is important to find strains that include high content of limonene. Most of the time, a flower from the cannabis plant only gives of traces of the limonene, but different strains will give off more of it depending on how the plants are grown and cured.
Some harvests test low for the limonene while others are surprisingly high. The harvest batches have to be tested to find the exact amounts so, to find the right strain at a medical collective, you have to ask. Some people will literally follow their noses when trying to find a good strain in a collective. If it smells lemony or citrusy, chances are it is high in limonene content and will make you feel euphoric, energized, de-stressed and creative.
Other uses for the limonene are for solvent products. It has been a great alternative to turpentine for stripping paint. It is preferred because it is harmless compared to things like airplane glues, and stamp glues. Limonene is also used for 3D printing and shows promise as being a biofuel. It does have the ability to combust in certain formulations.
It is a wonderful medicine but it also has great benefits that go beyond uses for the human body. When selecting a strain, if you cannot find the tell-tale smell right away, be sure to ask. Most of the strains will have names that indicate they possess the uplifting, beneficial terpene.